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Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level


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Título :
Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level
Autor :
Barrajón-Catalán, Enrique
Menéndez-Gutierrez, María P.
Falcó, Alberto  
Carrato, Alfredo
Saceda, Miguel
Micol, Vicente
Editor :
Elsevier
Departamento:
Departamentos de la UMH::Bioquímica y Biología Molecular
Fecha de publicación:
2010-04-28
URI :
https://hdl.handle.net/11000/31097
Resumen :
Trastuzumab (Herceptin™) targets the human epidermal growth factor receptor 2 (HER2), which is overexpressed in 20–30% of breast and ovarian cancers carrying a bad prognosis. Our purpose was to target HER2-overexpressing human breast cancer cells with pegylated immunoliposomes bearing trastuzumab and containing melittin, which has recently shown anticancer properties. Using a panel of human breast cancer cells with different HER2 expression levels, these immunoliposomes decreased cancer cells viability in a dose–response manner and in correlation to their level of HER2 expression. Specific binding of the immunoliposomes to SKBr3 breast cancer cells was shown by ImageStream-based analysis. The morphological changes observed in the treated cells suggested a cytolytic process. This preclinical approach may suppose an effective strategy for the treatment of HER2-overexpressing tumors, and can support the development of an early phases I–II clinical trial. Trastuzumab resistant breast cancer cells (JIMT-1), can also be targeted using this approach.
Palabras clave/Materias:
Trastuzumab
Immunoliposomes
MelittinCell
Cell lysisHER2
HER2
Anticancer therapy
Breast cancer cells
Área de conocimiento :
CDU: Ciencias puras y naturales: Biología
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.1016/j.canlet.2009.09.010
Aparece en las colecciones:
Artículos Bioquímica y Biología Molecular



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.