Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/28627
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dc.contributor.authorElango, Jeevithan-
dc.contributor.authorBushin, Rodion-
dc.contributor.authorLijnev, Artiom-
dc.contributor.authorDe Aza, Piedad-
dc.contributor.authorPérez-Albacete Martínez, Carlos-
dc.contributor.authorGranero Marin, Jose Manuel-
dc.contributor.authorHernandez, Ana Belen-
dc.contributor.authorMeseguer-Olmo, Luis-
dc.contributor.authorMaté Sánchez de Va´, José Eduardo-
dc.date.accessioned2022-12-14T12:12:28Z-
dc.date.available2022-12-14T12:12:28Z-
dc.date.created2022-09-
dc.identifier.citationCells; v. 11, nº 19es_ES
dc.identifier.issn2073-4409-
dc.identifier.urihttps://hdl.handle.net/11000/28627-
dc.description.abstractHydroxyapatite (HA) is a hard mineral component of mineralized tissues, mainly composed of calcium and phosphate. Due to its bioavailability, HA is potentially used for the repair and regeneration of mineralized tissues. For this purpose, the properties of HA are significantly improved by adding natural and synthetic materials. In this sense, the germanium (Ge) mineral was loaded in HA biomaterial by cold isostatic pressure for the first time and characterization and biocompatibility using bone marrow mesenchymal stem cells (BM-MSCs) were investigated. The addition of Ge at 5% improved the solubility (3.32%), stiffness (18.34 MPa), water holding (31.27%) and biodegradation (21.87%) properties of HA, compared to control. Compared to all composite biomaterials, the drug-releasing behavior of HA-3% Ge was higher at pH 1 and 3 and the maximum drug release was obtained at pH 7 and 9 with HA-5% Ge biomaterials. Among the different mediums tested, the DMEM-medium showed a higher drug release rate, especially at 60 min. HA-Ge biomaterials showed better protein adhesion and apatite layer formation, which ultimately proves the compatibility in BM-MSCs culture. Except for higher concentrations of HA (5 and 10 mg/mL), the different concentrations of Ge and HA and wells coated with 1% of HA-1% Ge had higher BM-MSCs growth than control. All these findings concluded that the fabricated HA biomaterials loaded with Ge could be the potential biomaterial for culturing mammalian cells towards mineralized tissue repair and regeneration.es_ES
dc.description.sponsorshipThis research was funded by MCIN/AEI/10.13039/501100011033 Grant numbers PID2020-116693RB-C21 and PID2020-116693RB-C22-
dc.description.sponsorshipGeneralitat Valenciana Grant number CIAICO/2021/157-
dc.description.sponsorshipand Internal Research Fund from Universidad Católica San Antonio de Murcia (UCAM), Grant number PMAFI-27/21, Murcia, Spain.-
dc.formatapplication/pdfes_ES
dc.format.extent21es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectydroxyapatitees_ES
dc.subjectgermaniumes_ES
dc.subjectdrug releasees_ES
dc.subjectmesenchymal stem cellses_ES
dc.subjectprotein adhesiones_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnologíaes_ES
dc.titleThe Effect of Germanium‐Loaded Hydroxyapatite Biomaterials on Bone Marrow Mesenchymal Stem Cells Growthes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Bioingenieríaes_ES
dc.identifier.doi10.3390/cells11192993-
dc.relation.publisherversionhttps://doi.org/10.3390/cells11192993-
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